BIOM-56. MIR-497 AND 219 IN BLOOD AID MENINGIOMA CLASSIFICATIONMIR-497 AND 219 IN BLOOD AID MENINGIOMA CLASSIFICATION

Abstract There is a need for blood biomarkers meningioma. The role of circulating micro RNA in cancer diagnosis has been the objective several studies. One extensively studied miRNA different types microRNA-497 (miR-497). This study systematically evaluated miR-497 as meningioma biomarker disease and classification. We exosomal serum 74 samples (WHO grade I=25, WHO II=25, III=24), 53 healthy controls. also tested two normalisers, endogenous external, their impact on diagnostic value miR-497. Another microRNA miR-219, which increased with increasing tumour grade. combined miR-219 estimated sensitivity specificity joint to indicate relationship between expression level methylation class distinguished from control samples. Moreover, was suitable identifier When we efficacy higher than or when used individually Both showed noticeable change